Galantamine supplement side effects and benefits, use for Alzheimer’s disease and mental enhancement, memory improvement
Review of dosage recommendations, use with choline, generic over the counter
February 1 2017
Galantamine is a cholinergic medicine. It can be isolated from several plants, including daffodil bulbs, but is now synthesized. It is available over the counter and also by prescription.
Galantamine offsets reductions in central cholinergic neurotransmission in Alzheimer’s disease by specifically and reversibly inhibiting acetylcholinesterase enzyme. This allows more acetylcholine to be available in the brain. It is also a nicotinic receptor agonist. Another herbal extract that has potential in the therapy of Alzheimer’s disease is Huperzine A.
Being approved for the treatment of Alzheimer’s disease in both the US and in Europe, galantamine has potential as therapy for dementia. Galantamine is currently not recommended for use by young individuals.
Galantamine side effects, safety, concerns, danger
Cholinesterase inhibitors should be used with caution. Side effects of galantamine are similar to those of other cholinesterase inhibitors. High doses may lead to side effects such as nausea, vomiting, diarrhea, abdominal pain, and dyspepsia.
An alternative to galantamine supplements
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Safety and efficacy of galantamine (Reminyl) in severe Alzheimer’s disease (the SERAD study): a randomised, placebo-controlled, double-blind trial.
Lancet Neurol. 2009: University of Manchester, Manchester, UK.
The efficacy of galantamine has been shown in patients with mild, moderate, and advanced moderate Alzheimer’s disease. Here we report its efficacy in patients with severe AD. Between 2003 and 2007 patients aged 84 years with severe AD in a nursing home setting were randomly assigned to receive galantamine, titrated initially to 24 mg/day, or placebo. The brain medication improved cognitive function but failed to significantly improve the co-primary parameter of overall activities of daily living.
Economic and clinical benefits of galantamine in the treatment of mild to moderate Alzheimer’s disease in a Korean population: a 52-week prospective study.
J Korean Med Sci. 2008. Department of Psychiatry, Hallym University College of Medicine, Seoul, Korea.
Patients received either galantamine treatment or no treatment. The analysis was performed from a societal perspective. Galantamine treatment reduced time spent caring for the patients and maintained improved functional capacity, whereas, when no treatments were given, a great increase in caregiver time and progressive functional deteriorations were observed. Galantamine had a beneficial effect not only to slow functional decline in patients with mild to moderate AD, but also to save a substantial amount of costs, closely related to reduction in caregiver burden and decrease in caregiver time.
Galantamine for Nerve Gas Exposure
Treatment with galantamine in combination with atropine, protects guinea pigs from lethal doses of the nerve agents sarin and soman and the insecticide parathion. The toxic effect of these “organophosphorus” compounds derives from irreversible blockage of an enzyme critical to nerve function. The end result can be seizures and cardiac arrest. At present, atropine and other drugs are used to treat the toxic effects of organophosphorus compounds. However, these treatments have various limitations, including an inability to fully protect the brain from damage. Galantamine protects nerves from these chemicals by temporarily blocking the same enzyme. Researchers tested the effects of galantamine in guinea pigs exposed to lethal doses of sarin, soman, and paraoxon, the biologically active form of parathion. Atropine was given to counter the effects of these agents outside the brain. Galantamine plus atropine safely and effectively counteracted the toxic effects of the organophosphorus compounds. Moreover, galantamine was well tolerated at the dosages needed to prevent death. Proceeding of the National Academy of Sciences, 2006.
Galantamine Research studies
Indicators of neuroprotection with galantamine.
Brain Res Bull. 2005. Geerts H. In Silico Biosciences, Berwyn, PA
Data suggest a role for cholinergic stimulation, especially the alpha7 nicotinic acetylcholine receptors (nAChR), in beta-amyloid-mediated neurotoxicity. The review presents the preclinical evidence in Alzheimer-related models of neuroprotection with galantamine, especially in models related to glutamate and beta-amyloid toxicity in vitro and to cholinergic stress in vivo. The review identifies possible clinical indicators, such as long-term studies, suggesting a neuroprotective effect for galantamine mediated by alpha7 nicotinic receptors. These clinically relevant neuroprotective properties of galantamine are worthwhile exploring further and their clinical relevance may improve the development of new disease-modifying agents.
This plant extract is also sold as Reminyl, a prescription medicine. As far as we know, galantamine and Reminyl are identical, but we really have not seen the exact chemical analysis of Reminyl drug to know for sure. As far as we know, the Razadyne generic name is galantamine.
I wish to take galantamine for memory I not worried about it and the stoke. My main concern was about its safety after hearing something about Reminyl for Alzheimer’s and 16 people dieing in trials. can you give you input?
We don’t have enough personal and professional experience to make any recommendations. We suggest having approval by your doctor and prefer other mind nutrients and consider galantamine as a supplement to be used only when the others are not effective.
Can an older man or woman take galantamine and Aricept together I’m out looking for answers to this question they told me tale Aricept one day then take galantamine the next and so forth till I get to the third week Is this a safe way to do it cautioned by research into this product.
Combining these medication products the same day may produce or increase side effects. We don’t have any experience with alternating the use of galantamine and Aricept, but this is an interesting idea and worth a try under medical supervision and in low dosages. An older person can have side effects to medications and supplements at a lower dosage than younger individuals, therefore the galantamine dosage and the Aricept dosage should be low even if one needs to take a portion of a tablet or capsule.